CBD and GABA: Natural Relaxation and Wellness Synergy Published on August 11, 2024 by Masha Burelo Index Toggle What is GABA?Emotions and sensations produced by GABAWhat effects does GABA produce?How is GABA obtained?What foods are rich in GABA?Can a diet rich in GABA increase its levels?What happens when there is a lack of GABA?What is CBD and its relationship with GABAEffects of CBD on GABAPotential Therapeutic Benefits of CBD + GABAEffects of THC on GABAConclusion In the search for natural methods to improve mental well-being and reduce anxiety, CBD and GABA have emerged as two key components. Although different in origin and function, their combination can offer benefits to promote relaxation and calmness. Today in Cannactiva ‘s post we explain what GABA is, its functions, how cannabis and CBD affect the levels of this neurotransmitter so important for relaxation and neuronal balance in our body. What is GABA? GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the brain, responsible for promoting relaxation. This neurotransmitter plays a crucial role in regulating the activity of neurons and maintaining a proper balance between excitation and calm in our brain (1). GABA is an essential neurotransmitter in our brain that regulates neuronal excitability and contributes to maintaining calm. GABA helps relax the nervous system by acting as a brake on the brain, reducing the activity or excitation of neurons. It works in conjunction with glutamate, which does the opposite and increases the excitability of neurons. Optimal brain functioning occurs from a proper balance of excitation (glutamate) and neuronal inhibition (GABA). Emotions and sensations produced by GABA GABA is known for its calming effects on the brain and body, helping to reduce stress and anxiety (3). However, more research is still needed to fully understand these effects. Neurons communicate through electrical signals called action potentials. These signals cause neurons to release neurotransmitters, which then activate other neurons. The action potential is the fundamental basis of neuronal communication, and GABA has the ability to prevent this communication from continuing, thus reducing the excitability of neurons. In fact, some antidepressant and anti-anxiety medications act on GABA, enhancing its action to alleviate symptoms of depression and anxiety. Examples of these drugs include benzodiazepines, such as diazepam (Valium) and alprazolam (Xanax), and certain anticonvulsants, such as valproic acid (Depakote) and gabapentin (Neurontin). Alcohol, for example, potentiates GABA and thus induces a sedative effect. However, withdrawal rapidly depletes GABA, resulting in symptoms of hyperexcitability such as anxiety, tremors, and even seizures. Anxiety and depression may be related to impaired regulation of the brain’s GABA system. That is why many antidepressant and anxiolytic drugs are focused on improving GABAergic activity. What effects does GABA produce? GABA decreases neuronal activity and prevents hyperactivity in the brain. It promotes relaxation and reduces stress responses, acting as a natural anxiolytic. It also promotes sleep and relaxation, functioning as a sedative, and helps reduce muscle tension, acting as a muscle relaxant. How is GABA obtained? GABA is produced naturally in the brain, from the amino acid glutamate (another neurotransmitter) and with the help of vitamin B6. In addition, GABA can be obtained from certain foods that are naturally rich in this neurotransmitter. What foods are rich in GABA? GABA can be found naturally in some foods. These include dairy products, especially fermented ones (yogurt, kefir), fish, nuts (cocoa or dark chocolate, almonds, walnuts, sunflower seeds), legumes (tofu, tempeh, lentils), edible mushrooms, oatmeal, spinach, tomatoes, broccoli and potatoes. In some countries there are already products enriched with GABA, and GABA supplements are also sold. Can a diet rich in GABA increase its levels? Yes, although the amount that actually reaches the brain and its effect may vary among individuals. Some research groups have found that feeding GABA-rich products may be beneficial in helping to treat anxiety and depression (8). In addition, lifestyle also influences its levels. What happens when there is a lack of GABA? It has been found that a decrease in GABA may be responsible for depression, mood changes, insomnia, anxiety, panic attacks and certain types of epilepsy (4, 5, 6, 7). What is CBD and its relationship with GABA CBD (cannabidiol) is a natural compound derived from the cannabis plant with no psychoactive effects and proven benefits on anxiety and pain, among other conditions. Both CBD and other cannabinoids can interact with several neurotransmitter systems, including GABA and GABAergic neurotransmission. Effects of CBD on GABA CBD, known for its calming and anxiolytic effects, can influence GABA levels in the brain and its activity. CBD can make more GABA available in the brain by preventing it from being degraded or reuptaken. In addition, CBD binds to specific receptors called GABA A, improving its effectiveness. All of this means that GABA can do its job of calming the brain better. In this way, cannabidiol could result in a more effective reduction of anxiety and an overall state of relaxation. Details: How do CBD and GABA interact? CBD has been shown to bind to GABA A receptors, increasing their efficacy and enhancing the inhibitory effects of GABA (10, 11). This modulation of GABA through CBD may contribute to the anxiolytic and anticonvulsant properties of CBD. On the other hand, CBD can inhibit the reuptake of a compound called adenosine, which could result in the modulation of GABA and glutamate release, affecting the overall excitatory/inhibitory balance in the CNS (12). CBD has shown significant potential in regulating GABA levels in the brain, offering wellness benefits. The exact mechanisms by which CBD influences GABAergic neurotransmission are complex and more research is still needed for the clinical application of CBD. Potential Therapeutic Benefits of CBD + GABA The effect of CBD on GABA has led to cannabidiol having prominent therapeutic uses in the treatment of anxiety and depression. The anxiolytic effects of CBD act through GABAergic modulation, although CBD is anxiolytic for many other reasons, such as its influence on the anandamide or serotonin cycle. The lack of significant side effects and low potential for dependence make CBD an attractive option for long-term use. The anticonvulsant properties of CBD have led to its approval for specific types of epilepsy. By enhancing GABAergic neurotransmission, CBD reduces the frequency and severity of seizures, offering a new avenue for patients who do not respond to traditional antiepileptic drugs. Effects of THC on GABA THC, the main cannabinoid contained in psychoactive marijuana-type cannabis, interacts mainly with the cannabinoid receptors CB1 and CB2 of the endocannabinoid system of the human organism. GABA-utilizing neurons also have these CB1 receptors, making them sensitive to the effects of THC. When THC binds to CB1 receptors on GABAergic neurons, it can reduce the release of GABA. Less GABA means there are fewer “brakes” on excitatory neuronal activity, which can increase signal transmission in the brain. This increased excitatory activity contributes to the psychoactive effects of THC, such as altered perception, mood changes and feelings of euphoria. In other words, THC has a different effect on the brain than CBD. Details: Effects of THC on GABA GABAergic neurons have CB1 receptors, so activation of these receptors by THC can reduce GABA release (9). As less GABA is released, inhibition of excitatory neurotransmission decreases. This may result in increased transmission of excitatory signals, contributing to some of the psychoactive effects of THC, such as altered perception, mood swings, and euphoria. Conclusion GABA is a neurotransmitter that helps calm brain activity. CBD can increase GABA levels in the brain, which helps reduce anxiety and improve well-being. However, the details of how CBD accomplishes this are not yet fully understood and require further research. THC, on the other hand, acts in the opposite way to CBD: it reduces GABA levels and increases neuronal excitability, which can lead to psychoactive effects such as euphoria and mood swings. Note: This is an informative article based on the latest scientific research. It is not intended to prevent, diagnose or treat any disease. Its contents may complement, but should never replace, any diagnosis or treatment of any disease or symptom. Cannactiva products are not medicines and are intended for external use. The authors and Cannactiva are not responsible for any misuse of this information. Please note that new scientific evidence may become available since the date of publication. Therefore, consult your doctor before using CBD or if you have any doubts about it. Sale Product on sale Full-Pack CBD – 5 Classic CBD Flowers + 3 Indoor CBD 91,39 € Original price was: 91,39 €.63,97 €Current price is: 63,97 €. Rated 4.83 out of 5 based on 52 customer ratings Select Sale Product on sale CBD Oil 20% Full Spectrum 55,16 € – 127,90 €Price range: 55,16 € through 127,90 € Rated 4.78 out of 5 based on 9 customer ratings Select CBD Oil 10% Full Spectrum 35,90 € – 71,60 €Price range: 35,90 € through 71,60 € Rated 4.86 out of 5 based on 28 customer ratings Select References Paz, Lenin & Gulias-Cañizo, Rosario & Ruíz-Leyja, Estela & Sánchez-Castillo, Hugo & Parodi, Jorge. (2021). The role of GABA neurotransmitter in the human central nervous system, physiology, and pathophysiology. Mexican Journal of Neuroscience. 22. https://doi.org/10.24875/RMN.20000050 Soghomonian, J. J., & Martin, D. L. (1998). Two isoforms of glutamate decarboxylase: why?. Trends in pharmacological sciences, 19(12), 500-505. https://doi.org/10.1016/s0165-6147(98)01270-x Hepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A. (2020). 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Molecules (Basel, Switzerland), 28(16), 5980. https://doi.org/10.3390/molecules28165980 Masha BureloInvestigadora en cannabinoides | Doctoranda en Neurociencia Masha Burelo es Maestra en Ciencias Farmacéuticas e investigadora en neurociencias. Actualmente está realizando su Doctorado en Neurociencia en la Universidad de Aberdeen, [...]
