Medicinal properties of THC

The cannabis plant has been used as a medicinal agent for centuries. Cannabis produces hundreds of compounds, including tetrahydrocannabinol (THC). THC, the psychoactive substance in cannabis, has been demonized by society for generations. However, with proper use, it can be an excellent treatment for some medical conditions.

Today in Cannactiva‘s blog, we review the beneficial properties that THC has demonstrated according to the latest scientific research. Note: This is an informational article and is not intended to prevent, diagnose or treat any disease.

History of medical cannabis

The medicinal use of cannabis has millenary roots, dating back to its cultivation in China around 4000 B.C., where it was used to treat various ailments. From there, it spread to India, the Middle East, Africa and Europe. However, the medicinal use of cannabis declined in the 20th century due to prohibitionist policies, legal restrictions and the variability of its effects.

However, the discovery of the endocannabinoid system in the 1990s renewed scientific interest in the cannabis plant. Today, medical cannabis is legal in many regions, backed by growing scientific evidence.

Medicinal uses of THC backed by scientific research

Chronic pain management

The use of cannabis to relieve chronic pain is the main reason mentioned by patients seeking medical treatment with this plant.

Studies have shown that a large majority of patients with medical marijuana cards use it to treat severe pain (5), and there are indications that many are substituting cannabis for opioids, significantly reducing the use of these conventional analgesics (6).

Although clinical trials suggest that plant cannabinoids can relieve pain (7, 8), research on the efficacy, dosage, methods of administration, and side effects of commercially available cannabis products remains insufficient.

Sleep disorders

THC may help in the treatment of short-term sleep disorders, especially in people with insomnia and other sleep-related disorders secondary to other medical conditions, such as pain (20).

By binding to cannabinoid receptors in the brain, THC can influence the release of neurotransmitters that promote sleepiness and reduce wakefulness, thus facilitating better sleep when used for short periods of time, as it could affect sleep quality in the long term (20).

Antiemetic

Drugs used in chemotherapy often cause nausea and vomiting as side effects. To treat these symptoms, several types of drugs, including the cannabinoids nabilone and dronabinol, have been approved since 1985 (1).

These oral drugs have been shown to be effective in controlling nausea and vomiting caused by chemotherapy, comparable to traditional treatments and superior to a placebo (2, 3), which has also been proven for THC in conjunction with CBD (4).Furthermore, the effects of cannabidiol (CBD) have not been studied in this context, which is a need expressed by patients who wish to avoid the psychoactive effects of THC. Research in this area could be important in the future.

Appetite stimulation

THC may increase food intake to prevent weight loss observed in some diseases, such as cancer or HIV/AIDS (9-12).

Small studies have indicated that cannabis increases appetite and caloric intake, mainly through increased snacking (13). While this may be due to the synergistic effect of many of the components of marijuana and not necessarily THC by itself, it is still a good choice as a cancer palliative.

Reduction of spasticity in multiple sclerosis (MS) or spinal cord injury

Spasticity, caused by damage to upper motor neurons, manifests as involuntary muscle contractions and affects people with chronic neurological diseases such as multiple sclerosis (MS) and paraplegia due to spinal cord injury (14). Some MS patients use cannabis to relieve symptoms, and studies suggest that certain oral THC extracts may slightly reduce spasticity as perceived by patients, although they have not consistently demonstrated improvements in medical evaluations (8, 15).

Tourette Syndrome

Tourette syndrome is a neurological condition that causes involuntary movements or sounds called “tics”. Although there is no cure, studies with THC have shown an improvement in the severity of tics (8, 16, 17).

No clear link between the syndrome and the mechanisms of cannabis has been demonstrated, although some reports suggest that it may reduce tics due to its anxiety-reducing effects.

Parkinson’s disease

Medical cannabis has shown improvement in tremors resulting from parkinsonism as reported by two research groups (17, 19). However, it does not appear to be helpful with involuntary movements induced by levodopa (17), which is the primary treatment for Parkinson’s disease.

Glaucoma

Glaucoma is a major cause of blindness and is characterized by damage to the optic nerve due to elevated eye pressure. Treatments focus on reducing this pressure.

Some studies suggest that marijuana may lower ocular pressure, but it does so temporarily (18). While an adequate treatment in the reduction of intraocular pressure should offer sustained effects, given that THC generates tolerance at some point and dose escalation implies more psychoactive effects for patients, it is not considered the best alternative.

Conclusion

THC has significant therapeutic potential, particularly for the management of symptoms of chronic diseases and certain health conditions. However, its use should be managed by a healthcare professional to minimize risks, especially considering individual variations in response to cannabis-based treatments. Although research on marijuana for medicinal uses is still ongoing, two major drawbacks of its use are the development of tolerance and the psychoactive effect.

Note: This is an informational article and is not intended to prevent, diagnose or treat any disease. Its content can complement, but should never replace, the diagnosis or treatment of any disease or symptom. Cannactiva products are not medicines and are intended for external use. There may be new relevant scientific evidence since the date of publication. Consult with your physician before using CBD. The therapeutic approach must always be personalized and will depend on the professional assessment.

References

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2. Phillips, R. S., Friend, A. J., Gibson, F., Houghton, E., Gopaul, S., Craig, J. V., & Pizer, B. (2016). Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood. The Cochrane database of systematic reviews, 2(2), CD007786. https://doi.org/10.1002/14651858.CD007786.pub3
3. Smith, L. A., Azariah, F., Lavender, V. T., Stoner, N. S., & Bettiol, S. (2015). Cannabinoids for nausea and vomiting in adults with cancer receiving chemotherapy. The Cochrane database of systematic reviews, 2015(11), CD009464. https://doi.org/10.1002/14651858.CD009464.pub2
4. Grimison, P., Mersiades, A., Kirby, A., Lintzeris, N., Morton, R., Haber, P., Olver, I., Walsh, A., McGregor, I., Cheung, Y., Tognela, A., Hahn, C., Briscoe, K., Aghmesheh, M., Fox, P., Abdi, E., Clarke, S., Della-Fiorentina, S., Shannon, J., Gedye, C., … Stockler, M. (2020). Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial. Annals of oncology : official journal of the European Society for Medical Oncology, 31(11), 1553-1560. https://doi. org/10.1016/j.annonc.2020.07.020
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