Anandamide: the THC produced by our body Published on May 25, 2024 by Masha Burelo Index Toggle What is anandamide?Where is anandamide produced?Anandamide and endocannabinoid systemWhat Effects does Anandamide have on the Body?Differences and similarities between anandamide, CBD and THCProperties of anandamideObesityCancerLiver cirrhosisNeuroprotectionCan anandamide be taken?Side effects of anandamideConclusion Anandamide is a fascinating molecule produced by our body that bears a striking similarity to tetrahydrocannabinol (THC), the main psychoactive compound in cannabis. In the Cannactiva blog, we explain what anandamide is, its function and benefits, as well as its relationship with cannabis. What is anandamide? The anandamide is a neurotransmitter with a molecular structure similar to THC. Its name comes from the Sanskrit “ananda”, meaning “inner happiness”, reflecting its role in modulating mood and feelings of happiness. Discovered in 1992 in the brain of pigs, anandamide was the first endocannabinoid ever identified, revealing that our body produces substances similar to the cannabinoids in cannabis. Its technical name is N-arachidonoylethanolamine (AEA), and it is a lipid neurotransmitter that could potentially be formed in any cell of the body, although it is found mainly in the brain. Where is anandamide produced? Although technically any cell in our body can produce anandamide, it is synthesized in greater quantities in different areas of the brain. In addition, it is also produced artificially in laboratories, especially for study in experimental models to understand its potential action in the human body. Anandamide and endocannabinoid system The endocannabinoid system (ECS) is a unique communication system in the brain and body that affects many crucial functions of the body, and aims to maintain its balance. Within this endocannabinoid system are endocannabinoids such as anandamide, which are substances produced by the body with the ability to bind and activate cannabinoid receptors and other cellular targets (1, 4). Anandamide is an endocannabinoid that binds to cannabinoid CB1 receptors in the brain in a manner similar to THC, influencing memory, appetite, stress, anxiety and inflammation. Anandamide binds to cannabinoid CB1 receptors, distributed in different areas of the brain (5), in much the same way as THC from cannabis does. What Effects does Anandamide have on the Body? Endocannabinoids such as anandamide are related to a wide variety of brain processes, such as memory formation, appetite induction, stress, anxiety and inflammation (7-10). Differences and similarities between anandamide, CBD and THC Anandamide, CBD (cannabidiol) and THC belong to the cannabinoid family, but differ significantly in their origin, function and effects on the human body. The first difference lies in their origin. Anandamide is produced naturally in our body, especially in the brain, while CBD and THC are produced in the trichomes of the cannabis plant. THC and anandamide are similar in their effects. The psychoactive component of marijuana and anandamide are similar in that they both bind to the same receptors in the brain (CB1), but THC does so more directly and potently, which allows it to have a psychoactive effect (3, 6). CBD can increase the levels of anandamide in our body. CBD, unlike anandamide and THC, does not bind directly to cannabinoid receptors, but acts indirectly by enhancing the effects of other brain chemicals, including serotonin and anandamide. In addition, CBD increases anandamide levels in our body, as it inhibits the enzyme that breaks down anandamide (24). In this way, CBD, through the action of anandamide, can act indirectly on CB1 receptors. Properties of anandamide Anandamide is linked to multiple brain processes. When diseases are present, the endocannabinoid system is imbalanced and altered, with overexpression of some receptors and endocannabinoids such as anandamide. Thus, that more anandamide is found in case of certain conditions, or more endocannabinoid receptors, is a result of the disease, but not vice versa. More information: Diseases related to anandamide dysregulation Problems in the regulation of anandamide are related to pathological processes, among which are: Obesity Anandamide is usually elevated in people with obesity and is associated with increased appetite and lack of satiety (11), which does not indicate that anandamide can be used to increase appetite, but rather that it is a biomarker for the detection of obesity. In the future, a strategy may be developed to reduce anandamide in the body and combat obesity. Cancer Elevated levels of anandamide have been found in different types of cancer, such as liver, urinary bladder and endometrial cancer in humans (12-15). In preliminary studies, it has been observed that disrupting the binding of anandamide to CB1 receptors and other cellular targets can reduce tumor development (15), but further studies are still needed to address this therapeutic potential of anandamide. Liver cirrhosis Anandamide levels appear to be elevated in liver cirrhosis, as in this medical condition there is an overexpression of CB1 receptors in the liver, which is not normal. Blockade of CB1 receptors to anandamide binding has been shown to decrease fibrosis and hepatic hypertension, representing a potential strategy for the treatment of this disease (16, 17). Neuroprotection Anandamide appears to be found in high amounts in neurodegenerative processes such as Parkinson’s disease and multiple sclerosis, in which it seems to have a neuroprotective effect through the activation of cannabinoid CB1 and CB2 receptors (18, 19) and other pathways involved in neuronal inflammation (20). Although this is in controversy, as CB1 receptor antagonism may reduce brain damage, at least in cases of cerebral ischemia (21). It is important to clarify that increasing anandamide through external substances does not cause a disease. Can anandamide be taken? Although anandamide is not available as a supplement, certain foods and compounds can increase its levels. It has been observed that chocolate can potentiate the effects of cannabis due to its lipid nature, increasing the levels of anandamide in our body and perhaps activating cannabinoid receptors (22). Consumption of foods such as chocolate is associated with positive effects, such as neuroprotection and a sense of well-being, since technically anandamide is like the THC of the brain. Chocolate is rich in anandamide, the cannabinoid-like compound that brings us happiness. In addition to chocolate, milk contains endocannabinoids, although not in sufficient quantities to produce a visible effect (23). Other substances can increase the levels of anandamide in our body, such as the aforementioned CBD or cannabidiol. CBD inhibits the enzyme that breaks down anandamide, which is the endocannabinoid enzyme FAAH. In this way, CBD, through the action of anandamide, can act indirectly on CB1 receptors. Side effects of anandamide Being a natural compound, anandamide itself does not usually cause adverse side effects. However, manipulating anandamide levels through external substances (such as CBD) could cause effects inherent to those external substances. Side Effects of CBD Conclusion Anandamide plays a key role in our sense of well-being and research is underway to better understand how naturally increasing anandamide levels through compounds such as CBD could result in beneficial effects on the body. We will keep you posted! References De Petrocellis, L., & Di Marzo, V. (2009). An introduction to the endocannabinoid system: from the early to the latest concepts. Best practice & research. 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Actualmente está realizando su Doctorado en Neurociencia en la Universidad de Aberdeen, [...]
